In everyday medical practice, clinicians often make small adjustments to a patient’s treatment plan—switching medications, updating dosages, or changing drug delivery methods. Most of the time, these changes improve symptoms and enhance quality of life. But occasionally, a routine decision can uncover something completely unexpected.
This was the case for a 55-year-old woman living with chronic obstructive pulmonary disease (COPD). For years, she had been stable on her medications. Then, following a switch to a new inhaler, she developed a painful and rare skin condition known as Sweet syndrome—a reaction so unusual that it may represent the first documented case linked to inhaled therapy.
